I have heard TSW guru Dr. Rapaport discuss the possibility of infection with a compromised skin barrier. It is generally not a concern. That said, my dermatologist was concerned and took a swab sample from my foot when I was there last Tuesday. I got a phone call today and was told it came back positive for MRSA, Methicillin-resistant Staphylococcus aureus. Great. Now I am on Doxycycline Hyclate pills, Mupirocin ointment, and Hibiclens antiseptic cleanser.